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4. All services | Lansing - McCoy's Guide
Kitra Somers. Picture of Kitra Somers. Escorts. in Lansing. Hotel incalls & outcalls in and around Lansing. (001) 517 803 7793. Adult Services. Recently added ...
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6. Encounter: Kitra returns! - ECCIE Worldwide
Default Encounter: Kitra returns! User ID: - Date: First week of March Name: Kitra Somers Phone: 5176040048. Email Address: KitraSomers@gmail.com. URL ...
Encounter: Kitra returns! Encounter Reports - Michigan
7. [PDF] Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra ...
ZielenskaG. Somers. Medicine. Human pathology. 2012. 153 Citations. Add to Library. Alert. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing- ...
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8. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra ...
Nov 1, 2019 · & Somers, G. R. The CIC-DUX4 fusion transcript is present in a subgroup of pediatric primitive round cell sarcomas. Hum. pathol. 43, 180–189 ...
Approximately 60–70% of EWSR1-negative small blue round cell sarcomas harbour a rearrangement of CIC, most commonly CIC-DUX4. CIC-DUX4 sarcoma (CDS) is an aggressive and often fatal high-grade sarcoma appearing predominantly in children and young adults. Although cell lines and their xenograft models are essential tools for basic research and development of antitumour drugs, few cell lines currently exist for CDS. We successfully established a novel human CDS cell line designated Kitra-SRS and developed orthotopic tumour xenografts in nude mice. The CIC-DUX4 fusion gene in Kitra-SRS cells was generated by t(12;19) complex chromosomal rearrangements with an insertion of a chromosome segment including a DUX4 pseudogene component. Kitra-SRS xenografts were histologically similar to the original tumour and exhibited metastatic potential to the lungs. Kitra-SRS cells displayed autocrine activation of the insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1R) pathway. Accordingly, treatment with the IGF-1R inhibitor, linsitinib, attenuated Kitra-SRS cell growth and IGF-1-induced activation of IGF-1R/AKT signalling both in vitro and in vivo. Furthermore, upon screening 1134 FDA-approved drugs, the responses of Kitra-SRS cells to anticancer drugs appeared to reflect those of the primary tumour. Our model will be a useful modality for investigating the molecular pathology and therapy of CDS.
9. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit ...
We confirmed that the Kitra-SRS sarcoma cell line expresses a CIC-DUX4 fusion mRNA containing the terminal 98 amino acids of DUX4 as previously described (Nakai ...
DUX4 activates the first wave of zygotic gene expression in the early embryo. Mis-expression of DUX4 in skeletal muscle causes facioscapulohumeral dystrophy (FSHD), whereas expression in cancers suppresses IFNγ induction of major histocompatibility ...
10. Endocrine outcome in children with medulloblastoma treated with 18 Gy ...
Dacou-Voutetakis C, Kitra V, Grafakos S, Polychronopoulou S, Drakopoulou M, Haidas S. Auxologic data and hormonal profile in long-term survivors of ...
Craniospinal radiation therapy (CSRT) combined with chemotherapy results in significant endocrine morbidity. Between 1987 and 1990, a trial using 18 Gy was conducted to treat 10 young children with medulloblastoma. There were 7 survivors. We compared ...
